I have been obsessing again on how we can move forward with baby make'n. I have been searching the Internet for the DOR's key to success.
I have found a few things. One seems very promising, unfortunately is not being studied in the United States, it is called human Nuclear Transfer or Cytoplasmic Nuclear Transfer, also called three parent baby. It "involves transferring part of one woman's egg into another's. In this case, scientists use the healthy portion of a donor egg (the cytoplasm) to supplement the defective portion of the infertile recipient's egg and to help it survive, hence making one good egg. The infertile woman's genetic legacy is preserved because the nucleus, which makes up 99 percent of the genetic material that determines physical traits in the embryo"
(Read more: here).
Although trials are not being conducted in the United States, there is a scientist, Jonathan Tilly, Ph.D., who discovered stem cells in mice that reproduce oocytes (eggs). He believes these stems cells are present in humans. He feels " these oocyte stem cells are the source for the woman's own germ-line mitochondria that can be used to rejuvenate her eggs", instead of using a donor's cytoplasm for optimal mitochondria. The article I read stated the company he has co-founded called Ova-Science is going to conduct a clinical trial doing the Cytoplasmic Nuclear Transfer, using the retrieved stem cells. This clinical trial will be conducted in women from 35-42 years old, so I will not qualify. I am highly considering emailing Dr. Tilly to see if they will be conducting clinical trials to women who have premature DOR.
I have also been cruising clinicaltrials.gov looking for studies I qualify for. So today I have emailed two contacts for two clinical trials, one is in SF. It is called "delayed start to ovarian stimulation". This study hypotheses is "delayed [the] start (7 day) to ovarian stimulation with an GnRH antagonist (Ganirelix) will improve oocyte maturation and quality, and improve pregnancy outcomes. The other trial is taking place at Cornell it is a "Low-dose Clomiphene Based Antagonist Protocol vs. High Dose Gonadotropin/Antagonist Protocol for IVF Poor Responders."
I know I'm grasping at straws, but we do not have the money right now for further IVF's, and the protocols I have tried have not worked. Why can't I move onto what we know's works DE? I want to have a Mindy/Whistler baby and while I still have eggs I want to use them.
